Biopharma and FACS core facilities

On-chip Sort, The world’s first cell sorter using adisposable microfluidic chip, designed for BioPharma andFACS Core Facilities

On-chip Sort the microfluidic chip cell sorter

The On-chip Sort is the world's first cell sorter using a disposable microfluidic chip. Utilizing the advanced microfluidic technology and micro-molding technology, we have developed the world’s first microfluidic chip-based sorter. Cell sorting has never been easier than with our disposable microfluidic chip- based system. The product is designed to fit the demands of BioPharma and FACS Core facilities.

Points to consider when selecting Cell Sorter and Advantage of On-chip Sort

Company	On-chip Sort	A	B	C	D
Company		A	B	C	D
Sorting Method	Air sort/Flow shift	Jet in air	Jet in air	Jet in air	On-chip piezo acoustic actuator
Flow Path	Microfluidic chip	Sorting chip	Tubing system	Tubing system	Tubing system
Max Lasers (colors)	3(6)	4(6)	3(4)	3(9)	1(3)
Purity	>95%	>99%	>99%	>99%	>98%
Cell damage	NO Damage	YES	YES	YES	YES
Application variety	YES	YES	YES	YES	NO
Contamination Risk	NO	NO	YES	YES	YES

On-chip Sorter meets the demands of both Biopharma and FACS Core facilities

Needs for Research

Minimal Cell Damage
On board laser/colors
Cell purity
Application variety
No contamination risks

Advantages

	On-chip Sort
Sorting	Air sort/Flow shift
Cell damage	No Damage
Max Lasers (colors)	3(6)
Purity	>95%
Application variety	YES
Flow Path	Microfluidic Chip
Contamination Risk	No Contamination Risks

Benefits

No cross contamination
Easy to use for downstream applications without cell damage
Variety of Fluorescent usability
Sort away from wanted cells
Capable of sorting a variety of cells
Broad selection of sheath fluid
Take out - redundant
No need washing for fluidics system

Advantages of On-chip Sort

Damage & Maintenance-free

From cell damage to contamination, On-chip cell sorter solves the problems of conventional cell sorters altogether.
Utilizing the most advanced microfluidic technology and micro-molding technology, we have developed a unique “microfluidic chip-based sorting” for the first time in the world. Cell sorting has never been easier with the exchangeable chip with in-built fluidic system. On-chip innovation beyond a cell sorter, that is what we are here to offer.

	Conventional Sorter	On-chip Sort
Cell Damage	Sorter-induced cellular stress	Damage-free
Contamination	Possibility of cross- contamination	Sterile and contamination-free
Instrument Size	Commonly large	Small enough to fit inside a biosafety cabinet
Cell Size	Typically < 40μm	As large as 140μm
Sheath Fluid	Particular sheath fluid required	Choose from a variety of media

SORTING TECHNOLOGY

Jet-in-air or Cuvette hybrid cell sorters have multiple processes that triggers sorter-induced cellular stress (SICS). On-chip Sort allows for much gentler sorting of cells compared to conventional sorters by the use of microfluidic chip.

	Conventional Sorter	On-chip Sort
Sorting Pressure	Approx. 40psi	Approx. 0.3psi
High-speed Collision	Cells collide at high-speed when collected	No collision
Electrostatic Charging	Cells are stressed due to charging	No electrostatic charging
Aerosol Generation	Potentially hazardous for users	No aerosols
Sorting Medium	Must use specified sorting medium	Most standard media accepted
Washing	Post-sort wash with harsh chemicals	No post-sort washing

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